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  2. Reagents
  3. Clinical Chemistry Reagents

Clinical Chemistry Reagents Reagents

HUMAN‘s clinical chemistry reagents are characterized by a long shelf life, open vial stability and onboard stability. Liquid and ready-to-use reagents allow for a secure ease of use.

HUMAN's multipurpose reagents are designed for manual procedures in combination with photometric reading or automated processing on clinical chemistry analyzers. HUMAN's working reagent procedures enable a quick, simplified and reliable manual processing.

HUMAN's system reagents are ready to use and filled in barcoded reagent containers, which can be directly loaded on the system. To ensure a high quality of analysis, thoroughly validated assay settings are included in the respective system software. Monitoring of onboard and calibration stability as well as reagent inventory is done automatically saving time and reducing errors.

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  • Clinical Chemistry Reagents

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The determination of total protein in urine supports the diagnosis and treatment of primary and secondary kidney disease and the diagnosis of diseases associated with cardiac and thyroid function. Increased total protein concentration in the urine (proteinuria) is a very common urinary finding and is one of the leading symptoms of kidney disease in addition to reduced eGFR.

Increased total protein concentrations in cerebrospinal fluid (CSF) are observed in a variety of disease states of the central nervous system (CNS), e.g. cerebral haemorrhage, bacterial or viral meningitis, inflammatory CNS disorders and tumors.

Colorimetric test for the quantitative determination of total protein in human urine and cerebrospinal fluid (CSF).
Albumin is the most important binding and transport protein of the organism. The multitude functions of albumin are: Major contribution to plasma colloidal osmotic pressure, binding and transport of proteins, metal ions, bilirubin, free fatty acids, hormones, drugs, serving as an amino acid pool for protein synthesis and major antioxidant in plasma. Albumin measurements are made for monitoring patients with acute liver diseases, for suspected liver cirrhosis and monitoring patients with this disease, diagnosis of edematous status, prognosis of elderly, hospitalized patients.

Colorimetric test for the quantitative determination of albumin in human serum and plasma.
Alkaline phosphatase activity is measured for diagnosis, monitoring and therapy control of liver, bone, parathyroid and intestinal diseases. Conditions with increased alkaline phosphatase levels are hepatobiliary diseases, primary and secondary bone diseases. Reduced alkaline phosphatase levels are found in familial hypophosphatasia, adynamic bone disease in dialysis patients, hypoparathyroidism, achondroplasia, pituitary dwarfism, chronic radiation sickness and malnutrition. Enzymatic color test for the quantitative determination of alkaline phosphatase in human serum and heparinised plasma.

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Alpha-amylase activity is measured for detection of acute pancreatitis, chronic (relapsing) pancreatitis, obstruction of the pancreatic duct, detection of pancreatic involvement in abdominal disorders, surgical procedures, anorexia, bulimia, and parotitis. There is also a detectable increase in amylase after an endoscopic retrograde cholangiopancreatography (ERCP) procedure.

Enzymatic color test for the quantitative determination of alpha-amylase in human serum, heparinised plasma and urine.
Latex slide test for non-diluted serum
The apolipoproteins B are the main protein components of low density lipoproteins (LDL-c). APO B is necessary for the reaction with LDL receptors in the liver and on cell membranes and is thus involved in transporting cholesterol from the liver to the vessel cells. Elevated levels of APO B are frequently found in atherosclerotic vascular changes and are a risk factor for atherosclerosis. Over the past several decades, decreased serum levels of high-density lipoprotein (HDL) and increased levels of low-density lipoprotein (LDL) have been associated with increased risk of coronary vascular disease.

Immunoturbidimetric test for the quantitative determination of apolipoprotein B in human serum.
Direct bilirubin (DBIL) is a helpful marker for hepatic and post-hepatic jaundice, whereas pre-hepatic jaundice is primarily associated with an increase of indirect bilirubin. Increased direct bilirubin concentrations are found in acute and chronic viral hepatitis, liver cirrhosis, hepatocellular carcinoma, extrahepatic cholestasis, liver transplant rejection, and congential disorders like Dubin-Johnson and Rotor syndrome.

Colorimetric test for the quantitative determination of bilirubin direct in human serum and plasma.
Latex slide test for non-diluted serum.
Complement C3 (C3c) is the central point of the classic and alternative complement pathway. C3c is a constituent of C5 convertase. On activation split products of C3c have important biological functions. C3b is an opsonin and involved in immune adherence, C3a is an anaphylatoxin and a chemotoxin. C3c behaves also like an acute phase protein, therefore increased levels may be found in acute inflammatory reactions. Decreased levels are reported in complex diseases, recurrent immune infections with pyrogenic bacteria, various glomerulonephritides and in congenital deficiencies.

Immunoturbidimetric test for the quantitative determination of complement C3 (C3c) in human serum.
Complement C4 (C4) is a constituent of C3 convertase and C5 convertase. Measurements of complement proteins aid in the diagnosis of immunologic disorders, especially those associated with deficiencies of complement components. Decreased levels are found in hereditary angioedema, immune complex diseases and congenital deficiencies.

Immunoturbidimetric test for the quantitative determination of complement 4 (C4) in human serum.
Calcium measurements are used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal disease and tetany (intermittent muscular contractions or spasms).

Colorimetric test for the quantitative determination of calcium total in human serum and heparinised plasma.
Chloride is the most important anion of sodium. Chloride is co-responsible for the extracellular fluid volume and plasma osmolality. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders, e.g. cystic fibrosis and diabetic ketoacidosis.

Colorimetric test for the quantitative determination of chloride in human serum, urine and cerebrospinal fluid (CSF).
Total cholesterol (CHOL) measurements are used for diagnosis and therapy control of atherosclerotic coronary vascular disease and metabolic disorders such as dyslipidemia and liver diseases. The concentration of total cholesterol in serum or plasma is influenced by different factors like age, sex, diet and physical activity.

Colorimetric enzymatic test for the quantitative determination of total cholesterol in human serum and plasma.
Cholinesterase activity measurements are used as a test of liver function in patients with acute and chronic hepatitis, liver sclerosis, as an indicator of insecticide poisoning and as a means to investigate atypical variants of the enzyme. A decreased level of enzyme activity is an indication of any of the above conditions. CHE is also used to identify patients with low enzyme activity before administration of muscle relaxants of the succinylcholine type. CHE activity is regarded as the most important indicator of degree of intoxication by organophosphorus pesticide.

Enzymatic colorimetric test for the quantitative determination of Cholinesterase in human serum and plasma.
Quantitative determination of creatine kinase-MB
Creatine kinase activity and the activity of its isoenzymes is measured for diagnosis and therapy control of myocardial infarction, myocarditis, cerebrovascular accidents, skeletal muscular dystrophies, and cardiac and skeletal muscle diseases. Creatine kinase activity is also measured for monitoring the treatment of cancer patients.

Enzymatic UV test for the quantitative determination of creatine kinase in human serum and plasma.
Creatinine (CREA) is a product of the muscle metabolism. Creatinine measurements are used for diagnosis and therapy control of renal diseases and monitoring renal dialysis. The concentration of creatinine is influenced by age, body weight, and sex. Urea/BUN and creatinine determinations are frequently performed together in the differential diagnosis of kidney function.

Colorimetric (Jaffé) and enzymatic tests for the quantitative determination of creatinine in human serum, plasma and urine. Creatinine concentration in urine is a calculation basis for other urine analytes.
Cystatin-C is as an excellent biomarker of the GFR and used for diagnosis and treatment of renal diseases. Cystatin-C is freely filtered through the glomerular membrane of the kidney and reabsorbed and degraded in the kidney cells. The concentration of Cystatin-C is only dependent on the glomerular filtration rate (GFR) itself.

Latex enhanced immunoturbidimetric test for the quantitative determination of Cystatin-C in human serum.

Quantitative determination of ferritin

Gamma-GT activity measurements are used for diagnosis of suspected hepatobiliary disease, differential diagnosis and monitoring of hepatobiliary disease and monitoring of chronic alcoholism in combination with other laboratory tests.

Enzymatic color test for the quantitative determination of gamma-GT in human serum and plasma.
Glucose (GLUC) measurements are used for diagnosis and therapy control of carbohydrate metabolism disorders. Elevated glucose values (hyperglycemia) are observed in the following discorders: diabetes mellitus, gestational diabetes and Addison's disease. Decreased glucose values (hypoglycemia) are observed in neonatal hypoglycemia, congenital enzyme defects, Reye's syndrome, hepatic dysfunction, insulinomas, insulin antibodies, alcohol ingestion, neoplasms, sepsis and chronic renal failure.
The determination of HbA1c is performed for the long term control in diabetes mellitus. HbA1c values provide an indication of the average glucose levels over the preceding 4-8 weeks. A high HbA1c value indicates poor glycemic control. Long term therapy of the disease requires control of blood glucose levels to prevent the acute complications of ketosis and hyperglycemia. In addition, preventing effective control of blood glucose levels can minimize long term complications such as retinopathy, neuropathy, and cardiovascular disease.

Immunoassay for the direct photometric determination of HbA1c in whole blood with EDTA.
Aminotransferases measurements are basic investigations for the diagnosis and monitoring of liver and muscle damage. Aminotransferases are measured for diagnosis and differential diagnosis of hepatobiliary disease (GPT/ALAT), myocardial infarction (GOT/ASAT), skeletal muscle damage (GOT/ASAT), viral hepatitis (GPT/ALAT) and as a part of medical screening examinations.

Enzymatic UV test for the quantitative determination of GOT/ASAT in human serum and plasma.
Aminotransferases measurements are basic investigations for the diagnosis and monitoring of liver and muscle damage. Aminotransferases are measured for diagnosis and differential diagnosis of hepatobiliary disease (GPT/ALAT), myocardial infarction (GOT/ASAT), skeletal muscle damage (GOT/ASAT), viral hepatitis (GPT/ALAT) and as a part of medical screening examinations.

Enzymatic UV test for the quantitative determination of GPT/ALAT in human serum and plasma.

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