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  2. Reagents
  3. Proteins

Proteins Reagents

HUMAN’s proteins reagents are optimized for the sensitive and precise quantification of serum proteins, such as albumin, globulins, and immunoglobulins. These reagents support diagnostic workflows in clinical chemistry and immunology, ensuring high-quality results. Designed for compatibility with automated systems, HUMAN’s proteins reagents enhance laboratory efficiency and diagnostic accuracy.

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  • Proteins

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The determination of total protein in urine supports the diagnosis and treatment of primary and secondary kidney disease and the diagnosis of diseases associated with cardiac and thyroid function. Increased total protein concentration in the urine (proteinuria) is a very common urinary finding and is one of the leading symptoms of kidney disease in addition to reduced eGFR.

Increased total protein concentrations in cerebrospinal fluid (CSF) are observed in a variety of disease states of the central nervous system (CNS), e.g. cerebral haemorrhage, bacterial or viral meningitis, inflammatory CNS disorders and tumors.

Colorimetric test for the quantitative determination of total protein in human urine and cerebrospinal fluid (CSF).
Albumin is the most important binding and transport protein of the organism. The multitude functions of albumin are: Major contribution to plasma colloidal osmotic pressure, binding and transport of proteins, metal ions, bilirubin, free fatty acids, hormones, drugs, serving as an amino acid pool for protein synthesis and major antioxidant in plasma. Albumin measurements are made for monitoring patients with acute liver diseases, for suspected liver cirrhosis and monitoring patients with this disease, diagnosis of edematous status, prognosis of elderly, hospitalized patients.

Colorimetric test for the quantitative determination of albumin in human serum and plasma.
Latex slide test for non-diluted serum
The apolipoproteins B are the main protein components of low density lipoproteins (LDL-c). APO B is necessary for the reaction with LDL receptors in the liver and on cell membranes and is thus involved in transporting cholesterol from the liver to the vessel cells. Elevated levels of APO B are frequently found in atherosclerotic vascular changes and are a risk factor for atherosclerosis. Over the past several decades, decreased serum levels of high-density lipoprotein (HDL) and increased levels of low-density lipoprotein (LDL) have been associated with increased risk of coronary vascular disease.

Immunoturbidimetric test for the quantitative determination of apolipoprotein B in human serum.
Latex slide test for non-diluted serum.
Complement C3 (C3c) is the central point of the classic and alternative complement pathway. C3c is a constituent of C5 convertase. On activation split products of C3c have important biological functions. C3b is an opsonin and involved in immune adherence, C3a is an anaphylatoxin and a chemotoxin. C3c behaves also like an acute phase protein, therefore increased levels may be found in acute inflammatory reactions. Decreased levels are reported in complex diseases, recurrent immune infections with pyrogenic bacteria, various glomerulonephritides and in congenital deficiencies.

Immunoturbidimetric test for the quantitative determination of complement C3 (C3c) in human serum.
Complement C4 (C4) is a constituent of C3 convertase and C5 convertase. Measurements of complement proteins aid in the diagnosis of immunologic disorders, especially those associated with deficiencies of complement components. Decreased levels are found in hereditary angioedema, immune complex diseases and congenital deficiencies.

Immunoturbidimetric test for the quantitative determination of complement 4 (C4) in human serum.
Cystatin-C is as an excellent biomarker of the GFR and used for diagnosis and treatment of renal diseases. Cystatin-C is freely filtered through the glomerular membrane of the kidney and reabsorbed and degraded in the kidney cells. The concentration of Cystatin-C is only dependent on the glomerular filtration rate (GFR) itself.

Latex enhanced immunoturbidimetric test for the quantitative determination of Cystatin-C in human serum.

Quantitative determination of ferritin

The determination of HbA1c is performed for the long term control in diabetes mellitus. HbA1c values provide an indication of the average glucose levels over the preceding 4-8 weeks. A high HbA1c value indicates poor glycemic control. Long term therapy of the disease requires control of blood glucose levels to prevent the acute complications of ketosis and hyperglycemia. In addition, preventing effective control of blood glucose levels can minimize long term complications such as retinopathy, neuropathy, and cardiovascular disease.

Immunoassay for the direct photometric determination of HbA1c in whole blood with EDTA.
The measurement of hemoglobin concentration is important for the diagnosis of anemia.

Colorimetric test for the quantitative determination of hemoglobin in capillary blood and whole blood with EDTA.
Homocysteine is an amino acid that is formed from the metabolism of dietary proteins. Elevated levels of homocysteine are associated with a significant higher risk of cardiovascular and peripheral arterial disease. The cause of elevated levels is related to the concentration of homocysteine measured in blood and is mostly associated with renal disease, low vitamin B and/or folat intake or inborn defects in the metabolism of the essential amino acid methionine (677C>T polymorphism of MTHFR gene).

Enzymatic UV test for the quantitative determination of homocysteine in human serum and plasma.
Immunoglobulins are the most important part of the humoral immune system of the organism. Of clinical interest are immunoglobulin deficiencies and increased levels of the immunoglobulins. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: Individuals with secretory IgA deficiency are found to suffer more commonly from mucosal infections, atopy, and autoimmune diseases. Individuals with absent IgA have a higher than expected incidence of rheumatic disorders and lymphoma.

Polyclonal gammopathies: Increased levels occur in chronic liver disease, chronic infections, especially of the gastrointestinal and respiratory tracts, neoplasia of the lower gastrointestinal tract, inflammatory bowel disease, some immunodeficiency states such as Wiskott-Aldrich syndrome and rheumatoid arthritis.

Monoclonal gammopathies: IgA multiple myeloma

Immunoturbidimetric test for the quantitative determination of immunoglobulin A (IgA) in human serum
IgG is particularly important in the body's long-term defence against infection as it presents a slower but more sustained response than IgM to primary antigenic stimulus; however, the levels of IgG rise rapidly and early on re-exposure to the same antigenic stimulus. IgG promotes phagocytosis and activates complement. IgG is the only immunoglobulin that crosses the placenta and is therefore of special importance in the infant’s defence against infection. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: IgG deficiency may be genetic as in severe combined immunodeficiency or acquired as in AIDS. Definitive diagnosis requires extensive evaluation in the immune response. A decrease in IgG also occurs as a result of thermal burns, nephrotic syndrome, protein losing enteropathies and non-IgG myelomas.

Polyclonal gammopathies: Increased levels of IgG in autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome), sarcoidosis, chronic liver disease, some parasitic diseases and chronic or recurrent infections.

Monoclonal gammopathies: e.g. in IgG type multiple myeloma, lymphomas, leukemia, and other malignancies.

Immunoturbidimetric test for the quantitative determination of immunoglobulin G (IgG) in human serum.
Immunoglobulins are the most important part of the humoral immune system of the organism. The essential functions of IgM in the immune response are the agglutination of pathogens and the activation of the classical complement pathway. Elevated levels of IgM in cord serum or during the first four weeks of life may indicate intrauterine or neonatal infections such as rubella, cytomegalovirus, toxoplasmosis or syphilis. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: IgM deficiency is rare and is associated with recurrent pyrogenic infections.

Polyclonal gammopathies: IgM levels are increased in primary biliary cirrhosis, haemoprotozoan infections such as malaria, viral or bacterial infections and rheumatoid arthritis.

Monoclonal gammopathies, e.g. in Waldenström’s macroglobulinemia and malignant lymphoma.

Immunoturbidimetric test for the quantitative determination of immunoglobulin M (IgM) in human serum.
Lp(a) is a risk factor for coronary vascular disease that is independent of all other lipid parameters. The Lp(a) concentration in blood varies from almost undetectable levels to more than 100 mg/dl. Differences in Lp(a) levels are genetically determined and will not be much influenced by lifestyle. The presence of high Lp(a) levels in serum is a significant marker for an increased risk of atherosclerosis and coronary vascular disease, especially when Lp(a) and LDL-c concentrations are elevated simultaneously.

Latex enhanced immunoturbidimetric test for the quantitative determination of lipoprotein (a) in human serum.
Microalbuminuria is considered a clinically important indicator of deteriorating renal function in diabetic subjects and regular screening is valuable in monitoring these patients. Prospective studies have demonstrated that increased urinary albumin excretion precedes and is highly predictive of diabetic nephropathy, end stage renal disease, and proliferative retinopathy in type I diabetes. In patients with type II diabetes increased urinary albumin excretion is an independent predictor of progressive renal disease, atherosclerotic disease and cardiovascular mortality. Increased urinary albumin excretion, both independently and in conjunction with hyperinsulinemia, identifies a group of nondiabetic subjects at increased risk of coronary vascular disease.

Immunoturbidimetric test for the quantitative determination of mircoalbumin in collected urine or random midstream urine.
Quantitative determination of IgM antibodies to rheumatoid factor.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 15 IU/ml
Transferrin is the principle plasma protein for the transport of iron. Transferrin is a negative acute phase reactant and will decrease during any inflammatory state or malignancy. Increased levels of transferrin are found in iron deficiency, pregnancy, oestrogen administration and lipoidal nephrosis. Decreased levels may be encountered in hereditary deficiencies, testosterone administration, infection, acute inflammation, some forms of nephrosis, tumors, haemochromatosis, acute malaria and malnutrition.

Immunoturbidimetric test for the quantitative determination of transferrin in human serum.

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