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  2. Instruments
  3. Clinical Chemistry
  4. HumaLyzer 4000

HumaLyzer 4000

CoreLab DXClinical ChemistryInstrumentsPhotometers
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A pioneer in the field of clinical chemistry photometers

The HumaLyzer 4000 was developed in collaboration with our affiliated company, LABiTec®, in accordance with the stringent European In Vitro Diagnostic (IVD) standards. This device is manufactured in Germany and has been successfully deployed in more than 70 countries worldwide.

HumaLyzer 4000 is the only photometer for routine applications that offers reference channel optics and allows remote-access for service. Together with many other new features, the HumaLyzer 4000 is a pioneer in the field of clinical chemistry photometers.

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Wavelengths: 8

340, 405, 505, 546, 578, 620, 700, 750 nm
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Integrated incubator

with 10 round and 2 square positions
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Color touchscreen

640 x 480 pixel
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5W reflector lamp

with safe mode for low energy consumption
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Comprehensive assay selection “Made in Germany”

More than 50 validated settings for HUMAN reagents, according to HUMAN's plug & run philosophy are preprogrammed
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Open channels

Flexibility with a total of 144 programmable settings
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Multi-language

Software in English, Spanish, French, German,
Russian and Ukrainian
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Intuitive and powerful software

Offers an enhanced user experience, designed for intuitive touchscreen interaction
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Efficient data management

Easy integration into laboratory information system with flexible connectivity options

Smart hardware solutions

  • Large touch screen
  • Low energy consumption
  • Lamp save mode – warm-up within seconds
  • Built-in incubator block 10 round and 2 square positions

Comprehensive assay selection “Made in Germany”

According to HUMAN's plug & run philosophy validated applications for the most HUMAN multipurpose reagents are preprogrammed.
HUMAN offers ready-to-use, liquid stable reagents in different convenient kit sizes.

Excellent data handling

  • Data management via onboard results, database, LIS or csv-export
  • Handheld barcode scanner for samples
  • External mouse and keyboard for quick input of patient data

User friendly

  • Simple update of software and settings via USB stick
  • Multilanguage interface
  • Fast Run or Worklist: customize your workflow
  • Automatic maintenance reminders (e.g. cleaning)

Robust and cost efficient

  • Service by user, no technician necessary
  • Lamp life time of > 5000 h
  • Basic wear and tear parts can be replaced without special tools by laboratory staff
  • No cleaning of interference filters required (sealed photometer module)

Tutorial videos for staff training and an easy start

Included with the HumaLyzer 4000 are 5 video training tutorials. Supplementing the user manual, these provide a quick visual overview of the functionality and operation of your new instrument.

Techspecs

Analyzer type

Semi-automatic photometer

Reagent system

Open

Reaction system

Flow cell or square cuvette

Analysis modes

End point, Fixed time,
Kinetic, Absorbance

Measuring modes

Photometry (colorimetry, UV-tests, turbidimetry)

Reference channel optics

8 different interference filters and 5W
halogen reflector lamp

Liquid handling

Peristaltic pump

QC module

Up to 4 levels of controls,
monitored via QC periods and
Levey Jennings charts

LIS

RJ-45 LAN (with proprietary protocol), uni-directional

Physical dimensions (W x D x H)

Instrument without any components: 31 x 37 x 19 cm
Space required for routine use: 75 x 80 x 50 cm
Weight: 4.3 kg

Environmental

Operating: temperature 15...32°C, humidity ≤ 85% non condensing
Transport: temperature 2...50°C, humidity ≤ 85% non-condensing

Downloads

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Flyer HumaLyzer 4000 EN

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    EN
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Flyer Clinical Chemistry Line EN

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    EN
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Flyer Clinical Chemistry Line ES

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    ES
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Flyer Clinical Chemistry Line FR

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    FR
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Flyer HumaLyzer 4000 ES

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    ES
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Flyer HumaLyzer 4000 FR

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Associated Products

Albumin is the most important binding and transport protein of the organism. The multitude functions of albumin are: Major contribution to plasma colloidal osmotic pressure, binding and transport of proteins, metal ions, bilirubin, free fatty acids, hormones, drugs, serving as an amino acid pool for protein synthesis and major antioxidant in plasma. Albumin measurements are made for monitoring patients with acute liver diseases, for suspected liver cirrhosis and monitoring patients with this disease, diagnosis of edematous status, prognosis of elderly, hospitalized patients.

Colorimetric test for the quantitative determination of albumin in human serum and plasma.
Alkaline phosphatase activity is measured for diagnosis, monitoring and therapy control of liver, bone, parathyroid and intestinal diseases. Conditions with increased alkaline phosphatase levels are hepatobiliary diseases, primary and secondary bone diseases. Reduced alkaline phosphatase levels are found in familial hypophosphatasia, adynamic bone disease in dialysis patients, hypoparathyroidism, achondroplasia, pituitary dwarfism, chronic radiation sickness and malnutrition. Enzymatic color test for the quantitative determination of alkaline phosphatase in human serum and heparinised plasma.

Related products:  » Calibrators: Autocal   » Controls: HumaTrol N/P, Serodos   » External Quality Assessment
Alpha-amylase activity is measured for detection of acute pancreatitis, chronic (relapsing) pancreatitis, obstruction of the pancreatic duct, detection of pancreatic involvement in abdominal disorders, surgical procedures, anorexia, bulimia, and parotitis. There is also a detectable increase in amylase after an endoscopic retrograde cholangiopancreatography (ERCP) procedure.

Enzymatic color test for the quantitative determination of alpha-amylase in human serum, heparinised plasma and urine.
Latex slide test for non-diluted serum
The apolipoproteins B are the main protein components of low density lipoproteins (LDL-c). APO B is necessary for the reaction with LDL receptors in the liver and on cell membranes and is thus involved in transporting cholesterol from the liver to the vessel cells. Elevated levels of APO B are frequently found in atherosclerotic vascular changes and are a risk factor for atherosclerosis. Over the past several decades, decreased serum levels of high-density lipoprotein (HDL) and increased levels of low-density lipoprotein (LDL) have been associated with increased risk of coronary vascular disease.

Immunoturbidimetric test for the quantitative determination of apolipoprotein B in human serum.
Direct bilirubin (DBIL) is a helpful marker for hepatic and post-hepatic jaundice, whereas pre-hepatic jaundice is primarily associated with an increase of indirect bilirubin. Increased direct bilirubin concentrations are found in acute and chronic viral hepatitis, liver cirrhosis, hepatocellular carcinoma, extrahepatic cholestasis, liver transplant rejection, and congential disorders like Dubin-Johnson and Rotor syndrome.

Colorimetric test for the quantitative determination of bilirubin direct in human serum and plasma.
Latex slide test for non-diluted serum.
Complement C4 (C4) is a constituent of C3 convertase and C5 convertase. Measurements of complement proteins aid in the diagnosis of immunologic disorders, especially those associated with deficiencies of complement components. Decreased levels are found in hereditary angioedema, immune complex diseases and congenital deficiencies.

Immunoturbidimetric test for the quantitative determination of complement 4 (C4) in human serum.
Calcium measurements are used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal disease and tetany (intermittent muscular contractions or spasms).

Colorimetric test for the quantitative determination of calcium total in human serum and heparinised plasma.
Chloride is the most important anion of sodium. Chloride is co-responsible for the extracellular fluid volume and plasma osmolality. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders, e.g. cystic fibrosis and diabetic ketoacidosis.

Colorimetric test for the quantitative determination of chloride in human serum, urine and cerebrospinal fluid (CSF).
Total cholesterol (CHOL) measurements are used for diagnosis and therapy control of atherosclerotic coronary vascular disease and metabolic disorders such as dyslipidemia and liver diseases. The concentration of total cholesterol in serum or plasma is influenced by different factors like age, sex, diet and physical activity.

Colorimetric enzymatic test for the quantitative determination of total cholesterol in human serum and plasma.
Cholinesterase activity measurements are used as a test of liver function in patients with acute and chronic hepatitis, liver sclerosis, as an indicator of insecticide poisoning and as a means to investigate atypical variants of the enzyme. A decreased level of enzyme activity is an indication of any of the above conditions. CHE is also used to identify patients with low enzyme activity before administration of muscle relaxants of the succinylcholine type. CHE activity is regarded as the most important indicator of degree of intoxication by organophosphorus pesticide.

Enzymatic colorimetric test for the quantitative determination of Cholinesterase in human serum and plasma.
Quantitative determination of creatine kinase-MB
Creatine kinase activity and the activity of its isoenzymes is measured for diagnosis and therapy control of myocardial infarction, myocarditis, cerebrovascular accidents, skeletal muscular dystrophies, and cardiac and skeletal muscle diseases. Creatine kinase activity is also measured for monitoring the treatment of cancer patients.

Enzymatic UV test for the quantitative determination of creatine kinase in human serum and plasma.
Creatinine (CREA) is a product of the muscle metabolism. Creatinine measurements are used for diagnosis and therapy control of renal diseases and monitoring renal dialysis. The concentration of creatinine is influenced by age, body weight, and sex. Urea/BUN and creatinine determinations are frequently performed together in the differential diagnosis of kidney function.

Colorimetric (Jaffé) and enzymatic tests for the quantitative determination of creatinine in human serum, plasma and urine. Creatinine concentration in urine is a calculation basis for other urine analytes.
Gamma-GT activity measurements are used for diagnosis of suspected hepatobiliary disease, differential diagnosis and monitoring of hepatobiliary disease and monitoring of chronic alcoholism in combination with other laboratory tests.

Enzymatic color test for the quantitative determination of gamma-GT in human serum and plasma.
Glucose (GLUC) measurements are used for diagnosis and therapy control of carbohydrate metabolism disorders. Elevated glucose values (hyperglycemia) are observed in the following discorders: diabetes mellitus, gestational diabetes and Addison's disease. Decreased glucose values (hypoglycemia) are observed in neonatal hypoglycemia, congenital enzyme defects, Reye's syndrome, hepatic dysfunction, insulinomas, insulin antibodies, alcohol ingestion, neoplasms, sepsis and chronic renal failure.
The determination of HbA1c is performed for the long term control in diabetes mellitus. HbA1c values provide an indication of the average glucose levels over the preceding 4-8 weeks. A high HbA1c value indicates poor glycemic control. Long term therapy of the disease requires control of blood glucose levels to prevent the acute complications of ketosis and hyperglycemia. In addition, preventing effective control of blood glucose levels can minimize long term complications such as retinopathy, neuropathy, and cardiovascular disease.

Immunoassay for the direct photometric determination of HbA1c in whole blood with EDTA.
Aminotransferases measurements are basic investigations for the diagnosis and monitoring of liver and muscle damage. Aminotransferases are measured for diagnosis and differential diagnosis of hepatobiliary disease (GPT/ALAT), myocardial infarction (GOT/ASAT), skeletal muscle damage (GOT/ASAT), viral hepatitis (GPT/ALAT) and as a part of medical screening examinations.

Enzymatic UV test for the quantitative determination of GOT/ASAT in human serum and plasma.
Aminotransferases measurements are basic investigations for the diagnosis and monitoring of liver and muscle damage. Aminotransferases are measured for diagnosis and differential diagnosis of hepatobiliary disease (GPT/ALAT), myocardial infarction (GOT/ASAT), skeletal muscle damage (GOT/ASAT), viral hepatitis (GPT/ALAT) and as a part of medical screening examinations.

Enzymatic UV test for the quantitative determination of GPT/ALAT in human serum and plasma.
HDL cholesterol (HDL-c) is regarded as a protecting lipid component against coronary vascular disease (CHD). Measurement of HDL-c cholesterol is used in the early recognition of ateriosclerotic risk and may also be used for therapy control during lipid lowering treatment. Together with LDL cholesterol it has a high diagnostic value to estimate the individual risk for CHD.

Homogeneous enzymatic color assay for the quantitative determination of HDL cholesterol in human serum and plasma.
The measurement of hemoglobin concentration is important for the diagnosis of anemia.

Colorimetric test for the quantitative determination of hemoglobin in capillary blood and whole blood with EDTA.
Kit specific control sera.
Liquid, low, medium and high level control based on human plasma.
Concentration stated on the vial label.
Immunoglobulins are the most important part of the humoral immune system of the organism. Of clinical interest are immunoglobulin deficiencies and increased levels of the immunoglobulins. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: Individuals with secretory IgA deficiency are found to suffer more commonly from mucosal infections, atopy, and autoimmune diseases. Individuals with absent IgA have a higher than expected incidence of rheumatic disorders and lymphoma.

Polyclonal gammopathies: Increased levels occur in chronic liver disease, chronic infections, especially of the gastrointestinal and respiratory tracts, neoplasia of the lower gastrointestinal tract, inflammatory bowel disease, some immunodeficiency states such as Wiskott-Aldrich syndrome and rheumatoid arthritis.

Monoclonal gammopathies: IgA multiple myeloma

Immunoturbidimetric test for the quantitative determination of immunoglobulin A (IgA) in human serum
IgG is particularly important in the body's long-term defence against infection as it presents a slower but more sustained response than IgM to primary antigenic stimulus; however, the levels of IgG rise rapidly and early on re-exposure to the same antigenic stimulus. IgG promotes phagocytosis and activates complement. IgG is the only immunoglobulin that crosses the placenta and is therefore of special importance in the infant’s defence against infection. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: IgG deficiency may be genetic as in severe combined immunodeficiency or acquired as in AIDS. Definitive diagnosis requires extensive evaluation in the immune response. A decrease in IgG also occurs as a result of thermal burns, nephrotic syndrome, protein losing enteropathies and non-IgG myelomas.

Polyclonal gammopathies: Increased levels of IgG in autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome), sarcoidosis, chronic liver disease, some parasitic diseases and chronic or recurrent infections.

Monoclonal gammopathies: e.g. in IgG type multiple myeloma, lymphomas, leukemia, and other malignancies.

Immunoturbidimetric test for the quantitative determination of immunoglobulin G (IgG) in human serum.
Immunoglobulins are the most important part of the humoral immune system of the organism. The essential functions of IgM in the immune response are the agglutination of pathogens and the activation of the classical complement pathway. Elevated levels of IgM in cord serum or during the first four weeks of life may indicate intrauterine or neonatal infections such as rubella, cytomegalovirus, toxoplasmosis or syphilis. Changes in serum immunoglobulin concentrations can be classified as follows:

Hypogammaglobulinemias: IgM deficiency is rare and is associated with recurrent pyrogenic infections.

Polyclonal gammopathies: IgM levels are increased in primary biliary cirrhosis, haemoprotozoan infections such as malaria, viral or bacterial infections and rheumatoid arthritis.

Monoclonal gammopathies, e.g. in Waldenström’s macroglobulinemia and malignant lymphoma.

Immunoturbidimetric test for the quantitative determination of immunoglobulin M (IgM) in human serum.
The iron and total iron binding capacity (TIBC) levels are influenced by changes in iron intake, absorption, storage, and release mechanisms. Such changes are indicative of a wide range of dysfunctions including anemias, nephrosis, cirrhosis and hepatitis. Iron measurements are interrelated parameters for the diagnosis of the iron status.

Colorimetric test for the quantitative determination of iron in human serum and heparinised plasma.
Lactate dehydrogenase measurements are used for diagnosis and therapy control of liver diseases such as acute viral hepatitis, cirrhosis, malignant liver diseases, myocardial infarction, tumors of the lung or kidneys, pulmonary embolism and hemolytic anemia.

Enzymatic UV test for the quantitative determination of lactate dehydrogenase in human serum and plasma.
LDL cholesterol (LDL-c) is an independent risk factor for coronary vascular disease (CHD). Epidemiological studies have shown the importance of LDL-c levels for the identification of high risk patients. HDL cholesterol (HDL-c) is regarded a protecting lipid component against coronary vascular disease (CHD). Together with HDL cholesterol LDL cholesterol has a high diagnostic value to estimate the individual risk for CHD.

Homogeneous enzymatic color assay for the quantitative determination of LDL cholesterol in human serum and plasma.
Lipase activity measurements are used primarily to investigate pancreatic disorders, usually pancreatitis. Indications for lipase measurements are detection and exclusion of acute pancreatitis (in acute upper quadrant abdominal pain), chronic (relapsing) pancreatitis, obstruction of the pancreatic duct and detection of pancreatic involvement in abdominal diseases.

Enzymatic colorimetric test for the quantitative determination of lipase in human serum and plasma.
Lp(a) is a risk factor for coronary vascular disease that is independent of all other lipid parameters. The Lp(a) concentration in blood varies from almost undetectable levels to more than 100 mg/dl. Differences in Lp(a) levels are genetically determined and will not be much influenced by lifestyle. The presence of high Lp(a) levels in serum is a significant marker for an increased risk of atherosclerosis and coronary vascular disease, especially when Lp(a) and LDL-c concentrations are elevated simultaneously.

Latex enhanced immunoturbidimetric test for the quantitative determination of lipoprotein (a) in human serum.
Pancreatic amylase activity measurements in serum and urine are mainly applied for the diagnosis of pancreatic disorders as well as for detecting the development of complications. As pancreatic and salivary amylase show a structural homology of 97%, the only method to distinguish is to use an assay based on monoclonal antibodies to inhibit the salivary enzyme. The amylase in the blood is eliminated through the kidneys and excreted into the urine, therefore, elevated serum activity is reflected in the rise of urinary amylase activity. For confirmation of an acute pancreatitis an additional measurement of lipase is recommended.

Enzymatic colorimetric test for the quantitative determination of pancreatic amylase in human serum, plasma and urine.
Inorganic phosphorus (PHOS, PO3) is measured for diagnosis and therapy control of various disorders such as bone diseases, chronic kidney disease, dialysis patients, kidney stones, after thyroid surgery, diseases of the parathyroid gland, chronic alcoholism, in intensive care (parenteral nutrition, ventilated patients), suspected Vit D deficiency, muscle weakness and bone pain.

UV test for quantitative determination of inorganic phosphate in human serum.
Potassium measurements are used in the diagnosis and treatment of hypokalemia (chronic ingestion of diuretics and laxatives, with/without disorders of the acid-base balance), hyperkalemia (overadministration of potassium, acidosis, or crush injuries), renal failure, Addison`s disease or other diseases involving electrolyte imbalance.

Photometric tests for the quantitative determination of potassium in human serum and heparinised plasma.
Quantitative determination of IgM antibodies to rheumatoid factor.
Calibration: 12.5 / 25 / 50 / 100 / 200 U/ml Cut-off: 15 IU/ml
Sodium measurements are used in the diagnosis and treatment of disturbances of fluid and electrolyte balance, e.g. due to a loss of water or salt, and other serum electrolytes deviating from their reference interval by polyuric-polydypsic syndromes and impaired thirst, renal diseases, hypertension, disorders of the acid-base balance, some endocrine diseases, edema, excessive sodium intake.

Colorimetric tests for the quantitative determination of sodium in human serum and heparinized plasma.
Total protein (TP) is a major component of blood and the sum of all circulating proteins. Total protein is measured for diagnosis and therapy control of a variety of diseases involving liver, kidney or bone marrow as well as other metabolic and nutritional disorders. Hypoproteinemia may be caused by abnormal synthesis, protein malnutrition, protein malabsorption, protein loss and after infusions. Hyperproteinemia may be caused by monoclonal gammopathy, severe chronic inflammatory and autoimmune processes.

Colorimetric test for the quantitative determination of total protein in human serum and plasma.
Transferrin is the principle plasma protein for the transport of iron. Transferrin is a negative acute phase reactant and will decrease during any inflammatory state or malignancy. Increased levels of transferrin are found in iron deficiency, pregnancy, oestrogen administration and lipoidal nephrosis. Decreased levels may be encountered in hereditary deficiencies, testosterone administration, infection, acute inflammation, some forms of nephrosis, tumors, haemochromatosis, acute malaria and malnutrition.

Immunoturbidimetric test for the quantitative determination of transferrin in human serum.
The measurement of triglycerides (TG) is used for diagnosis of primary and secondary hyperlipoproteinemias, primary and secondary prevention of coronary vascular disease (CHD), risk marker of metabolic syndrom, LDL-c calculation using the Friedewald formula as well as control of dietary and medical lipid lowering.

Enzymatic colorimetric test for the quantitative determination of triglycerides in human serum and plasma.
Urea (UREA, BUN) measurements are used in the diagnosis, differential diagnosis, assessment and therapy control of certain renal and metabolic diseases such as acute renal failure, terminal renal disease, and metabolic status of intensive care and dialysis patients. Urea and creatinine determinations are frequently performed together in the differential diagnosis of kidney function.

Conversion factor for UREA, BUN [mg/dl]
Conc. (UREA) = 2.14 x conc. (BUN); conc. (BUN) = 0.47 x conc. (UREA)

Enzymatic colorimetric test and fully enzymatic UV test for the quantitative determination of urea in human serum, plasma and urine.
Uric acid measurements are used in the diagnosis and therapy control of numerous renal and metabolic disorders, including chronic kidney disease, kidney stones, renal failure, gout, hyperlipidemia, leukemia, psoriasis, starvation or other wasting conditions and of patients receiving cytotoxic drugs or cyclosporine therapy in transplant recipients.

Enzymatic colorimetric test with or without ascorbate oxidase for the quantitative determination of uric acid in human serum, plasma and urine.

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